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Whipple’s disease Incidence: Rare disease Usually affects males Pathology: Histologically, the villi are stunted and contain diagnostic periodic acid-Schiff (PAS) positive macrophages. On EM, bacilli can be seen ‘within’ the macrophages The organism is similar to actinomycetes and has been given the name Tropheryma whippeii. Clinical features: Commonest presenting features: Steatorrhoea Abdominal pain Fever Weight loss Less common presenting features can include: Peripheral lymphadenopathy Arthritis Involvement of the: Heart Lung Brain Treatment: An antibiotic that crosses the blood-brain barrier (e.g. Chloramphenicol) |
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