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	Mechanisms of damage to peripheral nerves Overview: The peripheral nerve consists of 2 principle cellular structures: Axon Myelin sheath Blood supply to a peripheral nerve is via the vasa nervorum Mechanisms of damage: Demyelination (e.g. Guillain-Barre syndrome) Axonal degeneration (e.g. toxic neuropathies) Wallerian degeneration (describes the changes following section of a nerve) Compression (e.g. carpal tunnel syndrome) Infarction (e.g. diabetes mellitus, polyarteritis nodosa) Infiltration (e.g. malignancy, leprosy)
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