Metabolic neuropathies

Diabetes mellitus

Several varieties of neuropathy occur in diabetes mellitus:

• Symmetrical sensory polyneuropathy
• Acute painful neuropathy
• Mononeuropathy and multiple mononeuropathy:
• Cranial nerve lesions
• Isolated peripheral nerve lesions (e.g. median)

• Diabetic amyotrophy
• Autonomic neuropathy

Chronic uraemia:

• Progressive sensorimotor neuropathy occurs in chronic uraemia
• Variable response to dialysis
• Usually improves after renal transplantation

Thyroid disease:

A mild chronic sensorimotor neuropathy is sometimes seen in both thyrotoxicosis and hypothyroidism